Meta-Analysis Study on Treatment of Children's Attention Deficit Disorder with Hyperactivity

With the development of society and the economy, the prevalence of attention deficit hyperactivity disorder (ADHD) has been increasing. Due to its high comorbidity and high harm, it has received increasing attention. It causes damage to functions in multiple areas, and this damage may continue into adulthood. ADHD is a common developmental disorder characterized by persistent attention deficit and hyperactivity/impulsivity. ADHD often merges with other diseases, such as oppositional defiant disorder, conduct disorder, personality disorder, anxiety disorder, mood disorder, and substance dependence. The disease tends to cause children with learning difficulties, poor grades, strained relationships with family members and children of the same age, lack of self-esteem, and children with low occupation, low income, substance abuse, and antisocial personality characteristics when they grow up to adults. Many countries have formulated ADHD treatment guidelines for this purpose, but there is still a lack of consensus. This article uses literature research and the meta method: RevMan 5.3 software is used for data analysis. The analysis results show that traditional Chinese medicine has characteristics and advantages in the clinical total effective rate and hyperactivity index score in the treatment of ADHD. The overall clinical syndrome differentiation of the treatment can be summarized as liver and kidney yin deficiency and liver yang partial prosperity. The overall medication is based on the methods of nourishing yin and clearing heat, calming the liver and nourishing kidney, and nourishing yin and suppressing yang. The efficacy and safety evaluation of traditional Chinese medicine in the treatment of ADHD need to be further verified by large-sample clinical trials with strict design and standardized outcome index reporting.


Introduction
Attention deficit hyperactivity disorder is a common neurobehavioral disorder of school-age children, and its symptoms are characterized by attention deficit and hyperactivity impulse that are not commensurate with the level of development.
e global prevalence of children with ADHD has risen to 10%, and the prevalence of children in China is about 6.26%. With the spread of ADHD symptoms in society and the increasing importance of people on them, many parents and teachers will overdiagnose and improperly intervene in children's inattention and hyperactive behaviors in daily life. However, because it is difficult to diagnose the core symptoms of ADHD in the early stage, the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) have extended the age of onset of ADHD from 7 to 12 years.
is indicates that some school-age children have not been diagnosed but still show symptoms of ADHD, and the symptoms are at risk of continuous development. Studies have shown that children with ADHD symptoms are prone to academic problems, poor peer relationships, and offensive behaviors. eir symptoms persist into adulthood and are more related to offensive crime and antisocial behavior [3,4]. is article first introduces the treatment of children with ADHD, mainly from the two aspects of Western medicine and traditional Chinese medicine, including pathogenic factors and treatment methods. en it introduces the nondrug treatment of ADHD. is article mainly introduces parental training and art therapy. Finally, a systematic review and meta-analysis of the treatment of ADHD are carried out.

e Pathogenic Factors and Pathogenesis of ADHD.
e pathogenic factors of ADHD include genetics, neurophysiology, drug abuse during pregnancy, lead exposure, lack of early attachment, or childhood posttraumatic stress disorder. Genetic factors have always been considered to have an important relationship with the formation of ADHD [5,6]. Family studies have confirmed the general recurrence of diseases with a high genetic component. Compared with foster parents, the incidence of inherited ADHD from reproductive parents can reach more than three times. However, the genetic basis of this disease is more likely to be provided by the father of a child with ADHD. Environmental factors also have a certain impact on the occurrence of ADHD. Compared with decades ago, the incidence of this disease has increased. Complications during pregnancy or childhood may play a role in the occurrence of this disease. During pregnancy, exposure to harmful chemicals in the uterus may lead to the occurrence of ADHD [7,8]. ese factors include but are not limited to smoking, drinking, prescription drugs, illegal medicines, and environmental pollutants, have been ubiquitous in the past four decades and pose a threat to women. Toxemia, eclampsia, fetal overmaturity, delivery time, fetal distress, low birth weight, prenatal hemorrhage, or poor maternal health can all cause ADHD. Severe marital conflicts, low socioeconomic levels, parents with criminal records, those in foster care, and social psychosocial disorders are all related to ADHD. Any psychological factor that affects an individual's emotional health seems to play a role in the development and persistence of ADHD [9, 10].

Western Medicine Treatment of ADHD.
At present, the research on the treatment of ADHD mainly focuses on drug treatment, with less emphasis on psychotherapy and psychosocial intervention and less research on complementary and alternative drugs. e generally accepted standard method for the treatment of ADHD is pharmaceutical intervention, and the first choice is medical stimulants, such as methylphenidate (MPH) and dexamphetamine sulfate, of which methylphenidate is used in a wider range. In many western countries, the drugs currently used to treat ADHD include stimulants (methylphenidate, mixed amphetamine hydrochloride, etc.), nonstimulants (atomoxetine, clonidine, guanfacine, etc.), and some antidepressants (bupropion, venlafaxine, reboxetine, amitriptyline, etc.) [11,12].
In the past two decades, the number of ADHD patients has continued to increase. e long-term use of psychostimulants in children has been controversial. Due to the occurrence of side effects or lack of curative effect, poor compliance and treatment failure of patients generally occur. erefore, other alternative treatment options are welcome [13]. In different surveys conducted around the world, the use rate of complementary and alternative medicines (CAM) in Florida is 12%, in Boston 54%, Perth, in Australia, 64%, and in Melbourne 64%. e utilization rate in Israel is 28%. A study pointed out that compared with adolescents without mental health problems, the use rate of CAM therapy in the former (28.9%) is more than twice that of the latter (11.6%). e parent interview preparation technique is shown in Figure 1. e current literature reports many different complementary and alternative medicine (CAM) treatment methods, such as diet adjustment, physical therapy, massage, lifestyle changes, chiropractic treatment, acupuncture, and traditional Chinese medicine. ere is evidence that they can effectively improve the treatment of ADHD symptoms. Complementary and alternative medicine therapies, including traditional Chinese medicine, are widely used worldwide because they have fewer side effects and are safer [14,15].

ADHD in Traditional Chinese Medicine (TCM)
2.2.1. e Etiology and Pathogenesis of ADHD. When a child is born with inadequacy, improper postpartum care, improper education, environmental influences, trauma or emotional disorders, and so on, it will cause the five internal organs to lose coordination, qi and blood disorder, and corresponding diseases. e diagnosis and treatment of ADHD by traditional Chinese medicine are based on the unique overall concept and syndrome differentiation in the basic theories of traditional Chinese medicine [16]. It collects the clinical information of the patient through observation, hearing, inquiry, and combination of four diagnoses, making an accurate diagnosis and formulating a corresponding treatment plan.

TCM Treatment of ADHD.
e ultimate goal of TCM treatment of children with ADHD is to completely relieve it. e specific content is "when the patient is receiving or not receiving drug treatment, the clinical symptoms are reduced or disappeared, and the body's function reaches the best state." In other words, the standard for curative effect of traditional Chinese medicine treatment is that the core symptoms of ADHD are eliminated, the comorbidities are improved, and the children's behavior, mood, social function, and quality of life are maximized. TCM treatment also aims to strengthen the body's adaptability, eliminate endogenous and exogenous pathogenic factors, and eliminate the root cause of ADHD disease. At the same time, TCM treatment can strengthen and consolidate the effects of conventional medications, promote the gradual reduction of conventional medications within a safe range or even stop them completely, and help reduce side effects during treatment and the recurrence rate after treatment. Another goal of TCM treatment is to reduce the side effects of traditional medicines and reduce the cost of medical care.
When treating diseases, TCM will comprehensively consider five interrelated dimensions, namely real-time space-society-environment-psychobiology, which is slightly more complicated than the modern Western biologicalpsychosocial medicine model. e formulation of Western medicine treatment plans is often based on the results of laboratory tests so that drugs that target specific symptoms and biological mechanisms are used. However, Chinese medicine focuses on the overall improvement of all aspects centered on the patient.

Research on the Mechanism of Action of Traditional Chinese Medicine (1) Research on Monoamine Neurotransmitters and Related
Signal Pathways. Some experts have found that Anshen Dingzhiling can increase the relative expression of AC, cAMP, CDK5, p35, and CREB in the downstream signal pathway of DA and reduce the related expression of PP1 and DARPP32; related studies have found that Anshen Dingzhiling can reduce the correlation of dopamine transporters; it also increases the relative expression of dopamine DI and D2 receptors. Studies have shown that Anshen Dingzhiling can increase the expression of the specific protein SLOOP related to the growth and development of the nervous system. In summary, the mechanism of Anshen Dingzhiling is related to the dopamine signaling pathway and the norepinephrine system. Some experts believe that Duodongting decoction can regulate the expression level of the second messenger of monoamine neurotransmitters. Some researchers have found that Kong Sheng Zhen Zhong Dan can reduce the expression level of DAT and increase the expression level of TH in the prefrontal striatum, and the expression of DAT, DRD1, and DRD2 genes in the right brain is higher than that in the left brain. e possible mechanism of action of Dan is to regulate the prefrontal cortex in the brain. e DA nerve signal transduction of the striatum circuit can upregulate the expression levels of NET genes and proteins in the right prefrontal lobe and striatum. It is believed that the mechanism of Longmu Guizhi decoction is closely related to the norepinephrine system. Related studies have shown that Yizhining can increase the related expression of TH in the prefrontal lobe and striatum of SHR rats and reduce the related expression of DAT, DRD1, and DRD2.
(2) Research on Other Mechanisms. Studies have found that ginsenoside Rgl can increase the expression of a glial cellderived neurotrophic factor in SHR rats. Researchers found that acupuncture can reduce the expression of c-Fos in the hippocampus of mice and increase the related expression of Bcl-2. Its mechanism may be related to neuron protection and antiapoptosis.

Nondrug Treatment of ADHD.
When treating children with ADHD, it is difficult to expect satisfying results only by relying on drug therapy; especially, the additional consequences caused by lack of attention, impulsive solutions, lack of systematic thinking, and inefficient anger handling mechanisms, distorted relationships, and other problems cannot be solved by medication. erefore, not only medical treatment is needed, but we also need psychosocial treatment mechanisms. Commonly used psychotherapy methods include cognitive action therapy, parenting training, and so on.

Parenting Training.
e dimensions and types of parental rearing styles are shown in Tables 1 and 2.
Studies have shown that parental rearing style affects the symptoms of attention deficit and hyperactivity in schoolage children. is is consistent with the results of previous ADHD studies. Active parenting methods increase the protective function of ADHD children, and negative parenting methods increase the symptoms and negative emotions of ADHD children.
e results indicate that the authoritative parenting method is a more active and suitable parenting method for children with symptoms of attention deficit or hyperactivity, while the authoritarian parenting method can increase the symptoms of ADHD.
Studies have evaluated the parenting styles based on different reporters, and the results show the difference in the impact of parenting styles on ADHD between fathers and mothers. In the authoritative parenting style, only the authoritative parenting style evaluated by the mother as a protective factor negatively affects the symptoms of ADHD. Studies have found that the mother's self-evaluation authority score is significantly higher than that of his father's evaluation and that whether the mother evaluates herself or her husband's authoritative parenting style directly affects children's ADHD symptoms. ere was no  significant difference between the father's self-evaluated authority score and his mother's authority score, and neither the father's evaluation of himself nor his wife's authoritative parenting style was related to ADHD symptoms. e relevant results of the study show that the authoritative parenting styles under all reporting forms are negatively correlated with ADHD symptoms, but the path analysis results show that the authoritative parenting style evaluated by the father does not affect ADHD symptoms. erefore, some studies speculate that there is a possibility that fathers are not sensitive to the characteristics of authoritative parenting styles.
In addition, the results of children's reports of parental rearing styles showed that only the mother's authoritarian rearing styles positively affected ADHD symptoms. e mother's authoritarian parenting style is closely related to the inattention and hyperactivity of children aged 3-18. Calkins, Dedmon, Gill, Lomax, and Johnson's frustration research results also show that when mothers have too many intrusive behaviors and low sensitivity, young children have more negative emotions and show poor attention control ability. On the contrary, mother's positive response and warm and supportive behaviors can promote children's effort control and have a significant predictive effect on the later stage of children's effort control. is may be because the mother is the child's main caregiver and bears the main responsibility of nurturing in daily life. Parent-child interaction time is longer than that of the father. Autocratic mothers have more opportunities to pay attention to and control their children's ADHD symptoms.

Art erapy.
e art therapy items are mainly shown in Table 3.
Art is more useful for children whose language is not smooth enough, and art activities can provide an interesting environment for the children. In such an environment, the child treats the treatment project as a game and naturally integrates it into his/her environment. erefore, art therapy for children with ADHD is meaningful.

Developing Localized Evidence-Based Guidelines.
Treatment guidelines play a vital role in the prevention and treatment of ADHD. Evidence-based guidelines based on evidence-based methods have their own outstanding advantages. ere are already many evidence-based treatment guidelines for other physiological diseases in China, and it is necessary and urgent to formulate evidence-based treatment guidelines for ADHD. Foreign mature evidence-based guidelines provide reference evidence and mature treatment plans, and their concepts of evidence-based and collaboration are more worthy of reference. In the future, when formulating evidence-based guidelines in our country, we should combine localized research evidence and consider patients' personality characteristics and preferences to formulate localized evidence-based guidelines with scientific evidence, strong feasibility, and suitable for domestic conditions.

Paying More Attention to the Active Participation of
Families. According to foreign evidence-based guidelines, family participation is one of the most important contributors to the treatment effect and an important link that must be considered in the treatment process. As the first environmental system for individuals, the family has attracted the attention of researchers due to its unique position. e four evidence-based guidelines retrieved in this study all focus on family preference for treatment methods and the influence of the parent-child relationship on treatment results. Moreover, a large number of studies have shown that treatment methods such as group parent training programs, PBT, and PTBM have good effects on the treatment of ADHD; even for patients with severe symptoms, family participation can also play a good auxiliary role. In the future, our country should pay more attention to the active participation of families in the formulation of treatment guidelines, consider the preferences of families and patients on treatment options, give full play to the positive impact of the parent-child relationship on treatment, and help families  e treatment of ADHD is a long-term, multiparty collaborative process. At present, our country still lacks information communication and multiparty cooperation. Compared with foreign countries, domestic schools have an insufficient investment in ADHD treatment. Teachers' understanding of ADHD, adjustment of the teaching environment, curriculum settings, treatment referral, and other aspects need to be improved.
In the future, our country should build a multiparty ADHD prevention and treatment system, emphasizing family participation; formulating school intervention plans; attaching importance to social publicity, early detection, and early treatment; establishing a collaborative system of information exchange; and integrating family, school, and society into a system framework to participate in ADHD prevention and treatment.

Systematic Review and Meta-Analysis
Research on the Treatment of Children ADHD

Research Methods.
Search is conducted in six major databases; all search deadlines are until December 2020; search terms include Chinese medicine, herbal medicine, Chinese medicine (topic), attention deficit hyperactivity disorder (topic), hyperactivity, brain dysfunction, and random; and English search terms are traditional Chinese medicine, herbal medicine, attention deficit hyperactivity disorder, hyperactivity, and brain dysfunction. e collected data have been retrieved separately according to the characteristics of different databases. e technical route is shown in Figure 2.

Data Analysis. Data analysis mainly depends on heterogeneity detection.
d i is the individual study statistic, Var(d i ) is the variance of the statistic, Q is the chi-square statistic, and df is the degree of freedom.
e heterogeneity detection formula is as follows: where W i is the weight of each study, and the weight W i of each i-th study is calculated as follows:

Literature Search and Screening.
After searching six databases, 959 papers were retrieved; duplicates were removed; 75 were included after initial screening by reading the title and abstract; and 55 were further screened by reading the full text to exclude nonrandomized controlled trials and interventions that did not meet and duplicate studies. Finally, 20 papers were included, and the literature screening process is shown in Figure 3.

Improvement of Clinical Total Effective
Rate. e metaanalysis results showed that a total of 24 studies were included comparing traditional Chinese medicine and western medicine, with large heterogeneity (I 2 � 70%; P � 0.0001). Using a random effect model, the total clinical effectiveness of traditional Chinese medicine and western medicine was different. It is statistically significant (RR 1.27; 97% CI 1.20, 1.34; I 2 � 70%; n � 18). A total of 6 studies were included in the comparison of traditional Chinese medicine combined with western medicine and western medicine. e total clinical effective rate was compared, and the difference was statistically significant. Significance (RR 1.18; 95% CI 1.09, 1.28; I 2 � 59%; n � 2).

Publication Bias.
e type of intervention included in the study was compared with traditional Chinese medicine and Ritalin, and the results are shown in Figure 4.
In summary, traditional Chinese medicine has advantages in the total clinical effective rate, Conners hyperactivity index score, and reduction of clinical adverse reactions in the treatment of ADHD, especially in promoting the improvement of its overall clinical effectiveness and reducing clinical adverse reactions. It is superior to the conventional drug Ritalin and has obvious advantages in the treatment of ADHD. However, the results of the study show that in terms of the comparison of the outcome of traditional Chinese medicine treatment and Ritalin treatment, the overall clinical effective rate of the overall outcome shows that Chinese medicine treatment is due to Ritalin. e Conners hyperactivity index score shows that there is no statistical difference in the efficacy of Chinese medicine treatment and Ritalin treatment; secondly, the overall methodological bias risk of the included study is higher.

Conclusion
Traditional Chinese medicine treatment of ADHD has its own characteristics and advantages in terms of clinical total effective rate and hyperactivity index score. e overall clinical syndrome differentiation of treatment can be summarized as liver and kidney yin deficiency and liver yang partial prosperity. It should be noted that in this study, the conclusions mostly come from some small-sample studies with an uncertain risk of bias. e quantity and quality of the included literature, as well as the bias that may occur during the implementation of this study, can affect the quality of this meta-evaluation. However, this cannot be denied. e positive effect of the research, that is, the efficacy of the treatment of ADHD in children cannot be ignored. In the future, this research can be improved in the following aspects: (1) expand the search database, increase the sample size, and use more objective test indicators for literature screening; (2) expand the research object to make the research more meaningful; and (3) select high-quality literature; in the treatment process, the occurrence time, symptoms, duration, severity and disappearance time of adverse events should be determined and recorded in detail so as to obtain more effective scientific evidence.
Data Availability e data underlying the results presented in the study are available within the manuscript.

Conflicts of Interest
e authors declare no potential conflicts of interest.